Table 1.
Demographic Characteristics of Complete Cohort of 80 Dogs With Lymphoma and Restricted Group of 35 Dogs Analyzed by Gene Expression Profiling.
| Recruited Cohort (n = 80) No. (%) | GEP Cohort (n = 35)a No. (%) | Dogs Not on Array (n = 45) No. (%) | |
|---|---|---|---|
| Sex | |||
| Male | 48 (60) | 15 (43) | 33 (73) |
| Female | 32 (40) | 20 (57) | 12 (27) |
| Age at diagnosis, y | |||
| Median | 8.5 | 8 | 8.8 |
| Mean ± SD | 8.5 + 3.1 | 7.9 + 3.3 | 8.1 + 3.0 |
| Breed | |||
| Golden Retrievers | 50 (62) | 23 (66) | 27 (60) |
| All other breedsb | 30 (38) | 12 (34) | 18 (40) |
| Classificationc | |||
| LBT | 9 | 5 | 4 |
| PTCL | 5 | 4 | 1 |
| TZL | 12 | 8 | 4 |
| T-ALCL | 1 | 0 | 1 |
| DLBCL | 29 | 10 | 19 |
| BL | 8 | 2 | 6 |
| MZL | 13 | 5 | 8 |
| B-ALCL | 2 | 0 | 2 |
| NTNBL | 1 | 1 | 0 |
| Median survival, mo | |||
| All dogs | 6.6 (n = 80) | 8 (n = 35) | 6.2 (n = 45) |
| Standard of care | 8.5 (n = 54) | 10.0 (n = 22) | 8.0 (n = 32) |
| Other treatment | 6.1 (n = 15) | 10.5 (n = 5) | 5.6 (n = 8) |
| No treatment | 0.25 (n = 5) | 3.1 (n = 2) | 0.03 (n = 3) |
Gene expression profiling (GEP) cohort was divided into 2 groups with 29 and 6 dogs, respectively. The demographic data for the 2 cohorts were not significantly different; the group of 6 dogs included 1 PTCL, 3 TZL, and 2 DLBCL.
Airedale Terrier (n = 1), Beagle (n = 2), Bichon Frise (n = 1), Boxer n = 4), Labrador Retriever (n = 6), Mastiff (n = 3), Rottweiler (n = 4), Scottish Terrier (n = 1), Shih Tzu (n = 1), Terrier (n = 1), Toy Poodle (n = 1), West Highland Terrier (n = 1), mix breed (n = 2), unknown (n = 2).
LBT = lymphoblastic T-cell lymphoma; PTCL = peripheral T-cell lymphoma not otherwise specified; TZL = T-zone lymphoma; ALCL = anaplastic large cell lymphoma; DLBCL = diffuse large B-cell lymphoma; BL = Burkitt lymphomas; MZL = marginal-zone lymphoma; NTNBL = non-T, non-B-cell lymphoma.