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. 2015 Dec 17;10(12):e0144758. doi: 10.1371/journal.pone.0144758

Fig 6. Kinetics of γ-secretase cleavage was not altered by fenofibrate in cell free assay.

Fig 6

Levels of AICD were assessed by immunoblotting of HEK293T cells transfected with increasing quantity of APP C99 cDNA (A). The amounts of AICD generated from membranes treated with or without fenofibrate were the same regardless of starting amounts of transfected C99 cDNAs. (n = 6; averages ± S.E.). In (B), the levels of newly generated AICD were assayed from cells transfected with the same amount of C99 cDNA (1.5μg) and measured as a function of time. There was no change in the kinetics of AICD generation after treatment with fenofibrate (n = 6; averages ± S.E.).