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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Brain Res. 2015 Jun 17;1638(Pt B):183–198. doi: 10.1016/j.brainres.2015.06.009

Figure 1.

Figure 1

Epigenetic mechanisms regulating NG2 cell proliferation and differentiation during development.

OPC proliferation is controlled by epigenetic marks that activate cell cycle genes expression and repress mature genes expression. During the S phase, genetic and epigenetic marks are also tightly duplicated. Combined epigenetic marks, especially deacetylation and methylation, lead to cell cycle genes and inhibitor of differentiation genes repression during OL differentiation, while acetylation and hypomethylation induce expression of myelin genes like Mag.