Table 1.

Epigenetic enzymes required for normal oligodendrocyte development.

Enzyme	Modification	Required for	Experimental system
HDAC1/2	Histone de-acetylation	Specification, differentiation and myelination	Primary rodent OPC cultures (Marin-Husstege et al., 2002; Wu et al., 2012a), human OPC culture (Conway et al., 2012), zebrafish (Cunliffe and Casaccia-Bonnefil, 2006) and conditional knockout mice (Olig1-Cre) (Ye et al., 2009)
HDAC11	Histone de-acetylation	Differentiation	OPC cell line (Liu et al., 2009)
EZH2	H3K27 methylation	Specification	Neural stem cell culture (Sher et al., 2008)
G9a/SUV39h1	H3K9 methylation	Differentiation	Primary rodent OPC culture (Liu et al., 2015)
PRMT5	Histone arginine symmetric methylation	Differentiation	Primary rodent OPC culture and glioma cell line (Huang et al., 2011)
BRG1	Nucleosome remodeling	Differentiation and myelination	Primary rodent OPC culture and conditional knockout mice (Olig1-Cre) (Yu et al., 2013)
DICER	Process pre-microRNAs	Differentiation and myelination	Primary OPC cultures and conditional knockout mice (Plp-CreERT (Shin et al., 2009); Olig2-Cre and Cnp-Cre (Dugas et al., 2010); Olig1-Cre (Zhao et al., 2010))