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Modeling of the HP1γ auto-inhibited state. a Sequence alignment of the histone mimetic peptide of HP1γ (K82) with Histone 3 (K9), G9a (K185), and Histone 1.4 (K26). b Homology-based model of HP1γ in its autoinhibited state. c Homology-based model of the autoinhibited HP1γ homodimer. Together, these highlight the hypothesis that the ability of HP1γ to function as a histone mark reader is inhibited when both of its chromodomains are used to bind to additional monomers
