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. 2015 Dec 18;7:225. doi: 10.3389/fnagi.2015.00225

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Copyright © 2015 Seer, Fürkötter, Vogts, Lange, Abdulla, Dengler, Petri and Kopp.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A suggestion for post-hoc theoretical interpretation of the data. ALS-related prefrontal TDP-43 proteinopathy should be associated with measurable interindividual differences in executive functions. While response selection seems to be relatively unaffected by ALS (as revealed by normal RT, N2 amplitudes and s-LRP), enhanced posterior negativities in ALS patients might reflect functional compensation of executive deficits by stronger modulation of visual processing. LRP amplitudes were associated with EDF in ALS patients, pointing to a potential link between functional dysregulation in prefrontal and motor areas of the cortex. More error-prone behavior on the flanker task was also related to EDF in ALS patients.