Table 2.
Ranking of mpkCCD kinases with regard to likelihood of a role in phosphorylation of Ser261 of aquaporin-2, based on Bayesian integration of multiple data sets
| Mouse mpkCCD Cells* |
Mouse mpkCCD Cells (after colocalization data)† |
||||
|---|---|---|---|---|---|
| Rank | Kinase | Bayes' probability | Rank | Kinase | Bayes' probability |
| 1 | Mapk1 | 0.0237 | 1 | Mapk1 | 0.0393 |
| 1 | Mapk3 | 0.0237 | 1 | Mapk3 | 0.0393 |
| 1 | Mapk14 | 0.0237 | 3 | Mapk14 | 0.0349 |
| 4 | Gsk3a | 0.0174 | 4 | Cdk2 | 0.0218 |
| 5 | Cdk2 | 0.0131 | 4 | Cdk4 | 0.0218 |
| 5 | Cdk4 | 0.0131 | 4 | Mapk13 | 0.0218 |
| 5 | Cdk6 | 0.0131 | 7 | Srpk1 | 0.0194 |
| 5 | Cdk8 | 0.0131 | 7 | Nlk | 0.0194 |
| 5 | Cdk9 | 0.0131 | 7 | Gsk3b | 0.0194 |
| 5 | CdkL1 | 0.0131 | 7 | Cdk9 | 0.0194 |
| 5 | Clk1 | 0.0131 | 7 | Cdk6 | 0.0194 |
| 5 | Clk2 | 0.0131 | 7 | Mapk12 | 0.0194 |
| 5 | Dyrk1a | 0.0131 | |||
| 5 | Gsk3b | 0.0131 | |||
| 5 | Mapk12 | 0.0131 | |||
| 5 | Mapk13 | 0.0131 | |||
| 5 | Mapk6 | 0.0131 | |||
| 5 | Nlk | 0.0131 | |||
| 5 | Prpf4b | 0.0131 | |||
| 5 | Srpk1 | 0.0131 | |||
See Supplemental Data Set 6 for details of calculations.
*
From experiments in mpkCCD cells as described in text.
†
From the present study.