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. 2015 Oct 14;290(51):30204–30211. doi: 10.1074/jbc.R115.685990

FIGURE 2.

FIGURE 2.

Structural characterization of MR1-binding ligands derived from vitamin B synthetic intermediates. A, ternary structure of MR1 presenting 6-FP to MAIT TCR. Boxed area represents sections shown in more detail in B. B, contact between the MR1 bound antigens 6-FP, RL-6-Me-7-OH, 5-OP-RU, or non-covalently bound 5-OP-RU, with the MAIT TCR. C, contacts sequestering 6-FP, RL-6-Me-7-OH, 5-OP-RU, or non-covalently bound 5-OP-RU within the MR1-binding cleft. D, solvent-accessible area within the MR1-binding cleft with the A′- and F′-pockets labeled. The CDR3α (yellow) and CDR3β (orange) of the MAIT TCR are shown. E, Bistris propane bound within the F′-pocket of MR1 (from PDB ID: 4PJX). All dashed black lines represent hydrogen bonds, and red spheres represent water molecules.