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Chemical structures of glutamate conjugates and analogs found to be transported by ABCC5. A, in vivo substrates found through comparative metabolomics of wild type and Abcc5−/− mouse tissues. B, additional ABCC5 substrates identified through in vitro vesicular transport studies. MTX transport was shown by Wielinga et al. (14). Glutamate moieties are highlighted in red, whereas aspartate moieties are highlighted in blue.
