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. 2015 Oct 29;290(51):30429–30440. doi: 10.1074/jbc.M115.692103

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© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 3. — Nine metabolites accumulated in Abcc5^−/− tissues. Tissues of wild type and Abcc5^−/− mice were analyzed using untargeted LC-MS metabolomics, after which the data sets were compared using the XCMS online platform. Only metabolites that were significantly (p < 0.05) and over 2-fold increased in at least two Abcc5^−/− tissues are shown here. The elemental composition could be determined for a single unknown, whereas two other unknowns could not be identified beyond their mass over charge ratio (m/z). The metabolite concentrations in brains were relatively high and showed clear ABCC5 dependence. The data are presented on a log scale as means plus S.D. (n = 5 per genotype). AU, arbitrary units. p values were calculated using the Student's t test. *, p < 0.05; **, p < 0.01; ***, p < 0.001.