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. 2015 Oct 29;290(51):30429–30440. doi: 10.1074/jbc.M115.692103

FIGURE 4.

FIGURE 4.

The metabolites detected in our screen strongly accumulated in Abcc5−/− brain. Tissues of wild type and Abcc5−/− mice were analyzed using untargeted LC-MS metabolomics, after which the data sets were compared using the XCMS online platform. Of the nine metabolites that were significantly (p < 0.05) and over 2-fold increased in at least two Abcc5−/− tissues, eight accumulated in Abcc5−/− brain. Two unknowns could not be identified beyond their mass over charge ratio (m/z). The data are presented as means plus S.D. (n = 5 per genotype). AU, arbitrary units.