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Vesicular transport assays show that ABCC5 transports glutamate conjugates and analogs. Inside-out membrane vesicles without (control) or with ABCC5 (ABCC5) were incubated (10 min, 37 °C) with test substrates (100 μm) in the presence and absence of 5 mm ATP. The relative amount of test substrate in the vesicles was determined using LC-MS. The data are presented as means plus S.D. (n = 3). AU, arbitrary units; ND, not detected.
