FIGURE 11.

Mapping the binding site of compounds on the FZD8 CRD. Compounds that bind to the primary protein-protein interaction site of FZD8 CRD. A–E, ribbon representation of the backbone structure of mouse FZD8 CRD in complex with each compound. A, 3235-0367. B, 1094-0205. C, 2124-0331. D, NSC36784. E, NSC654259. F, 2% DMSO. The backbone thickness of the ribbon diagram is directly proportional to the weighted sum (in ppm) of the ¹H and ¹⁵N chemical shifts on binding to each compound. The program PyMOL was used to generate all figures.