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. 2015 Oct 26;290(51):30596–30606. doi: 10.1074/jbc.M115.673202

FIGURE 9.

FIGURE 9.

NMR analysis of compound binding to the mouse FZD8 CRD. Shown are the extended 1H-15N HSQC spectra of FZD8 CRD in the absence (blue) and the presence of compound (red). Compounds 3235-0367 (A), 1094-0205 (B), 2124-0331 (C), NSC36784 (D), and NSC654259 (E) were titrated into the solution of 15N-labeled mouse FZD8 CRD, respectively. The insets show the extended two-dimensional 1H-15N HSQC spectra of residue Leu97 at different concentrations of compound.