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. 2015 Oct 26;290(51):30607–30615. doi: 10.1074/jbc.M115.681627

FIGURE 1.

FIGURE 1.

FOXP1 regulates cellular glucose production in primary hepatocytes. A, real-time PCR analysis of FOXP1, G6PC, PEPCK, and PGC-1α expression levels in the liver of db/db mice (top panel), and FOXP1 expression level in the liver of ob/ob mice (middle panel) and their control mice. Western blotting analysis of FOXP1 protein amounts in the liver of db/db, ob/ob, and C57BL/6J mice (bottom panel). (n = 6 each group). B, Western blotting analysis of FOXP1 protein amounts in primary mouse hepatocytes infected with Ad-GFP or Ad-FOXP1 in the presence/absence of Dex and Fsk. C, real-time PCR analysis of G6PC, PEPCK, and PGC-1α expression levels in primary mouse hepatocytes treated as in B. D, measurement of cellular glucose output in primary mouse hepatocytes infected with Ad-GFP or Ad-FOXP1 in the presence of Dex and Fsk. Results are presented as mean ± S.D. of triplicate experiments. *, p < 0.05; **, p < 0.01.