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. 2015 Oct 26;290(51):30607–30615. doi: 10.1074/jbc.M115.681627

FIGURE 3.

FIGURE 3.

Overexpression of FOXP1 in the liver of db/db mice alleviates hyperglycemia. Male db/db mice were injected with Ad-GFP of Ad-FOXP1 as described under “Experimental Procedures.” A, real-time PCR analysis of mRNA levels of FOXP1, PEPCK, G6PC, and PGC-1α in the liver of Ad-GFP or Ad-FOXP1-injected db/db mice (n = 6 each group). B, Western blotting analysis of protein levels of FOXP1, PEPCK, and α-Tubulin in the liver of Ad-GFP or Ad-FOXP1-injected db/db mice (n = 6 each group). C and D, blood glucose levels of 6-h fasted (C) and 16-h fasted (D) db/db mice on day 5 after injection with the indicated adenovirus (n = 6 each group). E, pyruvate tolerance test (n = 6 each group). F, glucose tolerance test (n = 6 each group). *, p < 0.05; **, p < 0.01, mice injected with Ad-GFP versus mice injected with Ad-FOXP1.