Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Oct 29;290(51):30637–30647. doi: 10.1074/jbc.M115.689190

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

PMC Copyright notice

FIGURE 7. — Effects of IL-1β on iron homeostasis in mice. IL-1β was injected intraperitoneally at a dose of 250 ng/mouse. Groups of animals (n = 3/time point) were sacrificed at the indicated times after injection, and various parameters were analyzed. A, liver hepcidin expression. *, p = 0.02; **, p = 0.0002. Con, control. B, serum iron concentrations. *, p = 0.02. C, immunoblot of liver lysates with antibodies to phosphorylated SMAD1/5/8 (pSMAD1/5/8) or total SMAD1. D, quantitation of Western blots corresponding to C. The intensities of the phosphorylated SMAD1/5/8 and total SMAD1 bands in blots from multiple experiments were determined by Li-Cor imaging, and the ratio was calculated. *, p = 0.008; n = 3 samples/group (except for the 6-h time point, where n = 2) from multiple experiments.