Table 1.

Gene expression in Xbp1^fl/fl and Xbp1^−/− mice fed a HFS diet

	Xbp1fl/fl			Xbp1−/−
Genes	Chow	HFS 4 wk	HFS 16 wk	Chow	HFS 4 wk	HFS 16 wk
Fibrosis
Col1a1	1.01 ± 0.11	2.97 ± 0.98	3.20 ± 1.80*	2.33 ± 0.86	9.11 ± 4.80†‡	8.48 ± 4.12†§
Tgfβ1	0.95 ± 0.20	1.21 ± 0.24	2.28 ± 0.55*	1.69 ± 0.51	1.95 ± 0.44‡	4.41 ± 2.09†§
α-Sma	1.02 ± 0.24	1.35 ± 0.41	2.66 ± 1.46	1.11 ± 0.33	1.46 ± 0.51	2.96 ± 0.57†
Inflammatory markers
Cd68	0.90 ± 0.09	1.05 ± 0.16	1.11 ± 0.14	0.71 ± 0.01	1.78 ± 0.11†‡	1.20 ± 0.14†
Emr1	1.33 ± 0.37	1.59 ± 0.40	1.85 ± 0.36	1.12 ± 0.11	2.18 ± 0.12†‡	1.60 ± 0.20†
UPR pathway
Chop	1.01 ± 0.16	1.81 ± 0.46	1.71 ± 0.57	1.42 ± 0.33	6.95 ± 2.77†‡	2.39 ± 0.69
Bip	1.00 ± 0.08	0.81 ± 0.21	1.07 ± 0.36	0.43 ± 0.06*	0.52 ± 0.15‡	0.77 ± 0.18
Ire1α	1.21 ± 0.15	0.99 ± 0.13	0.94 ± 0.11*	1.45 ± 0.21	0.89 ± 0.09†	1.31 ± 0.36
Xbp1s	1.01 ± 0.13	1.24 ± 0.72	0.60 ± 0.12	n.d.	n.d.	n.d.
Atf6	0.94 ± 0.05	0.90 ± 0.09	1.23 ± 0.4	0.72 ± 0.03*	0.57 ± 0.02†‡	1.02 ± 0.21†
Atf4	1.02 ± 0.21	1.18 ± 0.32	1.85 ± 0.80	1.31 ± 0.54	1.85 ± 0.53	2.72 ± 0.52†
Other
Fgf21	1.45 ± 1.01	1.61 ± 0.78	3.18 ± 1.86	1.68 ± 1.16	5.96 ± 2.70†‡	4.08 ± 1.43

Values are means ± SD. HFS, high-fat/sugar diet.

^*P < 0.05 compared to Xbp1^fl/fl chow;

^†P < 0.05 compared to Xbp1^−/− chow;

^‡P < 0.05 compared to Xbp1^fl/fl HFS 4 wk;

^§P < 0.05 compared to Xbp1^fl/fl HFS 16 wk; n.d., not determined.