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. 2015 Sep 23;309(12):F1026–F1034. doi: 10.1152/ajprenal.00220.2015

Fig. 5.

Fig. 5.

Sodium balance, plasma sodium, and osmolality. A: daily Na balance. C: cumulative Na balance. HS, average of days 6–8 of HS treatment; HS + DOCP, average of days 17–19 of DOCP treatment. B and D: daily and cumulative Na balance, respectively, are shown for days 1–19. Solid lines are controls, and dotted lines are CD ET-1 KO. Control, n = 9; CD ET-1 KO, n = 6. E and F: Plasma Na and osmolality, respectively, are shown. Control, n = 4–11; CD ET-1 KO, n = 3–7. All data are shown as means + SE. In A and C, *P < 0.05 vs. control within same treatment, unpaired Student's t-test; †P < 0.05 vs. HS treatment within same genotype, paired Student's t-test. In B, *P < 0.05 within control, day 1 vs. days 2, 3, 6, and 7, Tukey's test; †P < 0.05 within control, day 11 vs. days 9–12 and 14–19, Tukey's test; ‡P < 0.05, significant effect of genotype, repeated-measures ANOVA. In D, *P < 0.05, significant effect of treatment within both genotypes, repeated-measures ANOVA; †P < 0.05 significant effect of treatment within both genotypes, repeated-measures ANOVA; ‡P < 0.05, significant effect of genotype, repeated-measures ANOVA, post hoc days 17–19. In E and F, *P < 0.05 vs. control within same treatment, unpaired Student's t-test; †P < 0.05 vs. NS treatment within the same genotype, unpaired Student's t-test.