Fig. 1.

In the second week of the experimental period, high salt (HS) intake elevated systolic blood pressure (SBP) and pulse pressure (PP), which were normalized by activin receptor-like kinase (ALK)5 inhibition. The arrows indicate the time of addition of vehicle (Veh) or SB-525334 (SB), and the dashed lines indicate BP responses of the animals that received this treatment. For Sprague-Dawley rats on the HS (8% NaCl) diet, SBP, diastolic blood pressure (DBP), and mean arterial pressure (MAP) during week 1 did not differ from rats on the low-salt (LS; 0.3% NaCl) diet. By the end of the second week, however, the HS diet increased daytime SBP, MAP, and both daytime and nighttime PP. ALK5 inhibition normalized these BP responses to the HS diet. Data are presented as means ± SE; n = 9 animals/group.