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. 2015 Oct 2;309(12):L1447–L1454. doi: 10.1152/ajplung.00262.2015

Table 2.

Axitinib reduces recruitment of leukocytes into the lung lining

Total Cells Macrophages Multinucleated Eosinophil Progenitors
Control/diluent 2.35 ± 0.15 2.35 ± 0.15 0 0 0
Control/axitinib 2.2 ± 0.48 2.2 ± 0.48 0 0 0
Tsc2-null/diluent 18.86 ± 1.09* 11.6 ± 0.74* 4.67 ± 0.60* 0.50 ± 0.30 2.34 ± 0.31*
Tsc2-null/axitinib 14.13 ± 1.28 9.95 ± 0.78 2.44 ± 0.42 0.35 ± 0.12 1.44 ± 0.33

Values are means ± SE of cell numbers × 105; n = 10 mice/group. Total cells were collected from lung lavage of control mice or mice with Tsc2-null lesions treated with diluent or axitinib at day 21 post-TMKOC cell injection. Total count was determined by Coulter counting; differential cell counts were done using Diff-Quick staining of cytospin slides. Cells were identified as macrophages, eosinophils, multinucleated, or progenitors by standard morphology. Comparisons between groups were made by two-way ANOVA and Bonferroni correction for multiple comparisons, P < 0.05 vs.

*

control/diluent group and

Tsc2-null/diluent group.