Table 2.

Axitinib reduces recruitment of leukocytes into the lung lining

	Total Cells	Macrophages	Multinucleated	Eosinophil	Progenitors
Control/diluent	2.35 ± 0.15	2.35 ± 0.15	0	0	0
Control/axitinib	2.2 ± 0.48	2.2 ± 0.48	0	0	0
Tsc2-null/diluent	18.86 ± 1.09*	11.6 ± 0.74*	4.67 ± 0.60*	0.50 ± 0.30	2.34 ± 0.31*
Tsc2-null/axitinib	14.13 ± 1.28†	9.95 ± 0.78	2.44 ± 0.42†	0.35 ± 0.12	1.44 ± 0.33†

Values are means ± SE of cell numbers × 10⁵; n = 10 mice/group. Total cells were collected from lung lavage of control mice or mice with Tsc2-null lesions treated with diluent or axitinib at day 21 post-TMKOC cell injection. Total count was determined by Coulter counting; differential cell counts were done using Diff-Quick staining of cytospin slides. Cells were identified as macrophages, eosinophils, multinucleated, or progenitors by standard morphology. Comparisons between groups were made by two-way ANOVA and Bonferroni correction for multiple comparisons, P < 0.05 vs.

^*control/diluent group and

^†Tsc2-null/diluent group.