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. 2015 Oct 23;309(12):L1478–L1486. doi: 10.1152/ajplung.00208.2015

Fig. 1.

Fig. 1.

A: original tracing for changes in right ventricular systolic pressure (RVSP) in response to U46619. B: dose-dependent increases in RVSP in response to U46619 in male (M) and female (F) wild-type (WT) mice and mice with genetic knockout (KO) of the gene for soluble epoxide hydrolase (sEH) (n = 6–9 in each group). *Curve of M-KO or F-WT mice shows significant enhancement compared with that of M-WT mice. #Curve of F-KO mice shows significant enhancement compared with those of other 3 groups of mice. C: effects of 14,15-epoxyeicosa-5(Z)-enoic acid (14,15-EEZE) on U46619 (0.2 nmol/g body wt)-induced increases in RVSP in the 4 groups of mice (n = 6–9 in each group). *Significant difference from M-KO mice. #Significant difference from F-KO mice. BW, body weight.