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Representative traces (A) and bar graph (B) showing mean ± SE change in [Ca2+]i in HLMVEC treated with the TRPV4 inhibitors RuR (20 μM) and HC-067047 (1 μM). ECIS traces (C) and bar graph (D) showing mean ± SE decrease in TER in HLMVEC following exposure to 250 μM H2O2 with and without HC pretreatment. For comparison purposes, the untreated H2O2 response shown in B is reproduced from Fig. 2. *Significant difference from control; n = 6–8 experiments/group, 20–40 cells/experiment.
