Fig. 1.
Cutaneous vascular conductance (%CVCmax) during supine passive heating in young (dash symbols) and older adults. The latter were tested after placebo (open symbols) and sapropterin administration (filled symbols). Data are shown at baseline and for each 0.1°C increase in esophageal temperature (Tes) throughout passive whole body heating. The increase in skin blood flow was blunted in older adults during placebo but was fully restored by sapropterin treatment. *P < 0.05, older placebo vs. young; †P < 0.05, older placebo vs. older sapropterin.