Fig. 3.
The change (represented by the solid arrow between data points) in the relation between SkBF and cardiac output for young (dash symbols) and older adults (placebo, open symbols; sapropterin, filled symbols) depicted for each transition between experimental conditions. A: transition from supine thermoneutral to supine heating to ΔTes = 0.8°C; B: transition from supine to upright posture while maintaining ΔTes at 0.8°C; C: transition from upright rest to upright dynamic exercise while maintaining ΔTes at 0.8°C. See text for further description.