Table 2.

Esophageal and mean skin temperature at each experimental phase

	Condition
	Thermoneutral		ΔTes = 0.4°C	ΔTes = 0.8°C
	Upright	Supine	Supine	Supine	Upright	Upright exercise	Supine exercise
Tes, °C
Young	37.2 ± 0.1	37.2 ± 0.1	37.6 ± 0.1	38.0 ± 0.1	38.0 ± 0.1	38.0 ± 0.1	38.1 ± 0.1
Older placebo	36.8 ± 0.1	36.8 ± 0.1	37.2 ± 0.1	37.6 ± 0.1	37.6 ± 0.1	37.7 ± 0.2	37.7 ± 0.2
Older sapropterin	36.8 ± 0.1	36.8 ± 0.1	37.2 ± 0.1	37.6 ± 0.1	37.6 ± 0.1	37.7 ± 0.2	37.7 ± 0.2
Mean Tsk, °C
Young	34.2 ± 0.2	34.1 ± 0.1	37.9 ± 0.2	38.3 ± 0.3	37.2 ± 0.2	36.7 ± 0.3	36.9 ± 0.2
Older placebo	34.3 ± 0.1	34.3 ± 0.1	38.1 ± 0.1	38.0 ± 0.1	37.3 ± 0.1	36.9 ± 0.1	36.9 ± 0.2
Older sapropterin	34.2 ± 0.1	34.1 ± 0.1	38.0 ± 0.2	38.0 ± 0.2	37.3 ± 0.2	37.0 ± 0.2	36.8 ± 0.2

Values are means ± SE. T_es, esophageal temperature; T_sk, skin temperature.