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. 2015 Oct 15;119(12):1374–1382. doi: 10.1152/japplphysiol.00699.2014

Fig. 1.

Fig. 1.

microRNA (miR) 206 is strongly upregulated in the lungs in monocrotaline (MCT)-pulmonary hypertension (PH), and genistein (GEN) therapy restores lung miR206 levels. A: heat map generated from the miR microarray analysis in the lungs of control (CTRL), PH, and GEN-rescue rats in the MCT model of PH (n = 4 rats/group). B: relative lung miR206 expression is confirmed using quantitative RT-PCR analysis in MCT model in CTRL, PH, GEN vehicle (VEH) CTRL (GEN-VEH), and GEN groups (n = 6–7 animals/group). PBS, phosphate-buffered saline. C: relative copy number of miR206 and other known miRs in PH, including miR21, miR322, and miR451, in the lungs of healthy CTRLs (n = 5 rats/group). Values are means ± SE. #P < 0.01. P̂ < 0.001.