Table 1B. Summary Data for Diagnosis of Acute Decompensated Heart Failure using NT-proBNP.

Author, Year	Renal Function Category	#	# ADHF (%)	AUC	Cut-point (pg/ml)	Sensitivity	Specificity
Anwaruddin, 2006	eGFR>=60	393	81 (21)	0.95	450*	0.85	0.88
	<60	206	129 (63)	NR	1200	0.89	0.72
Chenevier-Gobeaux, 2005	eGFR 60-89	141	28 (20)	0.85	1360	0.77	0.86
	30-59	187	64 (34)	0.73	1980	0.62	0.80
	15-29	41	20 (49)	0.80	6550	0.82	0.79
Colak, 2014	eGFR 30-90	NR	NR	0.72	3839	0.68	0.75
	<90	94	NR	0.66	3670	0.68	0.60
Coquet, 2008	eGFR >=60	98	39 (40)	0.76 (CI 0.69-0.83)	877	0.80	0.63
	<60	100	63 (63)	0.74 (CI 0.64-0.84)	3389	0.69	0.62
DeFilippi, 2007	eGFR >=60	438	197 (45)	0.74 (CI 0.70-0.79)	450*	0.81	0.52
	<60	393	240 (61)	0.66 (CI 0.60-0.71)	1200	0.81	0.49
Fu, 2013	eGFR>=60	641	147 (23)	0.72 (CI 0.67-0.77)	298	0.78	0.58
	<60	358	159 (44)	0.75 (CI 0.69-0.80)	436	0.89	0.53
Gorrison, 2007	eGFR>=60	39	NR	0.78	1118	0.85	0.73
	<60	41	NR	0.70	2592	0.70	0.64
Lefebvre, 2008	sCr<1.6	75	NR	0.69 (SE 0.08)	NR	NR	NR
	1.6-2.8	14	NR	0.66 (SE 0.10)	NR	NR	NR
	>2.8	15	NR	0.61 (SE 0.15)	NR	NR	NR
Park, 2010	Systolic HF eGFR>=60	NR	45	0.92	418	0.84	0.84
	eGFR<60	NR	55	0.83	1981	0.78	0.78
	Diastolic HF eGFR>=60	NR	36	0.89	276	0.83	0.83
	eGFR<60	NR	37	0.84	1733	0.78	0.76

eGFR, estimated GFR (1.73/ml/m²); sCr, serum creatinine (mg/dl); AUC, area under the curve; CI, confidence interval; SE, standard error; NR, not reported.

^*450 indicates >450 pg/ml in patients less than 50 years of age and >900 pg/ml in patients greater than 50 years of age (i.e. Standard Januzzi cut-points).