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Diagram of Sarcoplemmal mitochondria (SSM) and Interfibrillar mitochondria (IFM) in cardiac muscle (the EM image is from reference 6 with authors’ permission). Diabetic insult is currently reported to induce redistribution of specific microRNAs in these mitochondrial subpopulations, which may influence critical signaling events in sarcoplasmic reticulum (SR, the major Ca2+ storage site) and/or the contractile activity of myofibrils (MF) in cardiomyocytes.
