Fig. 9.

Reducing MnSOD activity enhanced NF-M expression at 48 and 72 h but diminished it at 96 h. Western Blot analysis of (A,B) NF-M and MnSOD (A,C) in SK-N-SH cells after incubation with either a control vector (Ctrl siRNA) or one targeting the MnSOD gene (SOD2 siRNA) and subsequent treatment with ATRA (10 μM) for 48, 72, and 96 h. n=6. *p<0.05 vs. CON-Ctrl siRNA per time point, ^†p<0.05 vs *. Kruskal–Wallis one way ANOVA on ranks. Results are expressed as fold changes vs. CON-Ctrl siRNA per time point±SEM.