FIGURE 13.

ErbB4 is required during Purkinje cells development. (A,B) WT (A,C,E) and KO (B,D,F) sections of cerebellum labeled with Calbindin (CB) at P21. CB+ Purkinje cells are distributed in a monolayer with their cellular bodies in the Pcl and their arborized dendritic trees embedded in the molecular layer (ml). This pattern is preserved in both WT and KO. However, in KO the Purkinje cells are reduced in size and in number and their dendritic trees are poorly developed. gl, granular layer. Scale bars: (A,B) (100 μm), (C,D) (50 μm) and (E,F) (25 μm).