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. 2015 Dec 18;9:472. doi: 10.3389/fncel.2015.00472

FIGURE 15.

FIGURE 15

Hippocampal development is compromised in the KO mice. (A,D) (P7) and (E,F) (P21) hippocampal sections of WT (A,C,E) and KO (B,D,F). (A,B) P7 Nissl staining shows a poorly developed hippocampus in the KO with a very rudimentary dentate gyrus (DG) and Cornus Ammonis (CA) fields. (C,D) At P7, the Calretinin (CR) and Reelin (Reln) interneuronal populations in the hippocampal strata lacunosum-moleculare (l-m), moleculare (m) and radiatum (r) are decreased in the KO compared to WT. (E,F) At P21, using Calretinin as a marker, I observe a fully developed dentate gyrus in WT. However, in the KO both dentate gyrus blades are thinner with a persistent migration of CR+ immature neuronal progenitors in the molecular layer (ml, inset in F). gcl, granular cell layer; h, hilus; HF, hippocampal fissure; o, strata oriens. Scale bars (A–D) (250 m) and (E,F) (125 μm).