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. 2015 Dec 18;9:472. doi: 10.3389/fncel.2015.00472

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Copyright © 2015 Perez-Garcia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The development of the astroglia is compromised in the KO. (A,B) (P0), (C–F) (P7), and (G,H) (P21) GFAP+ radial fibers are observed in WT from P0 to P7 whereas in KO the GFAP+ fibers are fragmented, misaligned, and reduced in number. At P7, an early astrogenesis is observed in the marginal zone (mz) in the KO with severe reduction in astrocytes in the svz. (E,F) are high power views of (C,D), respectively. (I), Quantification analysis indicates that the number of GFAP+ astrocytes in the cortical wall is significantly reduced by 46% (0.54 ± 0.01, p = 0.0005^∗∗∗, N = 4) in the KO compared to WT. I, cortical layer 1; wm: white matter. Scale bars: (A–D) (100 μm), (E,F) (50 μm) and (G,H) (125 μm).