FIGURE 5.

The oligodendroglia lineage, myelin production, and axonal growth are compromised in the KO. (A) Shown are cortical sections immunostained for MBP at P21 and in the adult. MBP+ mature oligodendrocytes are reduced in the KO versus WT when labeled with MBP. In the adult, ULs are significantly hypomyelinated in the KO compared to WT. (B) Shown are cortical sections co-immunostained for MBP and NFL at P21. Axonal development is reduced in the cortex in the KO, very significant in ULs. DL, deeper layers. Scale bar: (A) (100 μm) and (B) (125 μm).