Table 1. The association between IFNAR1 gene SNPs and EV71 HFMD susceptibility.
| SNP ID | Genotype | HD | EV71 | Multiplicative | Additive | Dominant | Recessive | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| No (%) | No (%) | P Value | OR (95% CI) | P Value | OR (95% CI) | P Value | OR (95% CI) | P Value | OR (95% CI) | ||
| rs2843710 | CC | 251 (43.8) | 442 (37.0) | 0.0001 | 1.34(1.15–1.55) | <0.0001 | 0.49(0.35–0.69) | 0.0002 | 0.54(0.39–0.74) | 0.005 | 1.33(1.09–1.63) |
| CG | 269 (46.9) | 565 (47.2) | 0.002 | 0.58(0.42-0.82) | |||||||
| GG | 53 (9.3) | 189 (15.8) | Ref. | Ref. | |||||||
| rs1787572 | GG | 196 (34.2) | 466 (39.0) | 0.2019 | 0.91(0.79–1.05) | 0.4725 | 0.89(0.66–1.21) | 0.8764 | 1.02(0.78–1.35) | 0.0530 | 0.81(0.66–1.00) |
| GT | 290 (50.6) | 545 (45.6) | 0.4067 | 1.13(0.85–1.52) | |||||||
| TT | 87 (15.2) | 185 (15.4) | Ref. | Ref. | |||||||
| rs113181057 | TT | 573(100.0) | 1196(100.0) | — | — | — | — | — | — | — | — |
| TC | 0 (0.0) | 0 (0.0) | — | — | |||||||
| CC | 0 (0.0) | 0 (0.0) | Ref. | Ref. | |||||||
| rs1012334 | AA | 195 (34.0) | 410 (34.3) | 0.2813 | 0.92(0.80–1.07) | 0.1516 | 0.81(0.60–1.08) | 0.0607 | 0.78(0.60–1.01) | 0.9175 | 0.99(0.80–1.22) |
| AT | 268 (46.8) | 599 (50.1) | 0.0517 | 0.76(0.58–1.00) | |||||||
| TT | 110 (19.2) | 187 (15.6) | Ref. | Ref. | |||||||
Note: Hardy-Weinberg equilibrium P values of 4 SNPs (in the order of rs2843710, rs17875752, rs113181057, rs1012334) were 0.11, 0.23, 0.00, and 0.30 in HD, and were 0.71, 0.22, 0.00, and 0.19 in EV71. Abbreviations: HD, healthy donors; EV71, EV71 HFMD; CI, confidence interval; OR, odds ratio.