Table 4.

EBC experiment and analysis parameters for studies of EBC in schizophrenia.

Study	Experiment parameters								Dependent variable quantification criteria
	ISI (ms)	Mean ITI (s)	Number of blocks	Trialsper block	Total trials(no. ofblocks)	Total no. paired trials	Pre-conditioning trials	Extinction trials	CR criterion (amplitude)	CR window (post-CS latency ms)
Taylor and Spence (54)	470	20	1	80	80 (1)	80	3 CS-alone, 1 US-alone	–	≥1 mm deflection of eyelid closure movement on polygraph (70)	200–470
O’Connor and Rawnsley (55)	350	Random b/t 20 and 40	1	48	48 (1)	30	3 CS-alone, 3 US-alone, 3 CS-alone	–	On CS-alone trials (n = 18) only: response amplitude 150% of maximum baseline amplitude (when cue light turned on before trial, 3–7 s pre-CS)	0–1.25 s post-CS onset for CS-alone test trials only
Spain (56)
Auditory	500	20 ms	1	50	50 (1)	50	–	–	Non-voluntary eyelid movement	200–500
Visual	500	20 ms	1	50	50 (1)	50	–	–	Non-voluntary eyelid movement	200–500
Sears et al. (57)	400	12	1	70	70 (1)	63	10 US-alone trials	40 unpaired CS or US trials	Amplitude exceeds 10% of baseline UR amplitude (measured from 10 US-alone trials pre-conditioning) for paired and CS-alone trials	200–400
Hofer et al. (58)	720	12	6	12	72 (6)	48	–	–	Change in the curve of eyelid data waveform exceeds 0.4 cm for at least 30 ms on S+ and S− trials (71)	390–720
Stevens et al. (59)	700	1100 ms	1	70	70 (1)	–	–	–	–	Eyeblink response must occur 200–700 post-CS onset on S+ and S− trials
Marenco et al. (60)
Trace	1540	18	7	11	77 (7)	70	10 CS-alone and 10 US-alone randomly presented	10 CS-alone and 10 US-alone randomly presented	Eyelid movement ≥0.5 mm for paired and CS-alone trials	150–1540
Delay	440	18	7	11	77 (7)	70	10 CS-alone and 10 US-alone randomly presented	10 CS-alone and 10 US-alone randomly presented	Eyelid movement ≥0.5 mm for paired and CS-alone trials	150–440
Brown et al. (61)	350	15	10	10	100 (10)	90	8 US-alone trials	20 CS-alone and 20 US-alone randomly presented	EMG amplitude over 5 SDs above pre-CS 125 ms baseline for each paired trial	100–350
Edwards et al. (62)	350	15	10	10	100 (10)	90	8 US-alone trials	–	EMG amplitude over 5 SDs above pre-CS 225 ms baseline for each paired trial	100–350
Bolbecker et al. (63)	350	15	10	10	100 (10)	90	8 US-alone trials	25 CS-alone and 25 US-alone randomly presented	EMG amplitude over 5 SDs above pre-CS 125 ms baseline for each paired trial	100–350
Bolbecker et al. (64)	250; 350; 550; 850	15	For each ISI: 5 (total = 10)	20	For each ISI: 100 (5) [total = 200 (10)]	For each ISI: 90 (total = 180)	8 US-alone trials	–	EMG amplitude over 5 SDs above pre-CS 125 ms baseline for each paired trial	150 pre-US onset
Forsyth et al. (65)	350	15	10	10	100 (10)	90	8 US-alone trials	–	EMG amplitude over 5 SDs above pre-CS 125 ms baseline for each paired trial	100–350
Parker et al. (66)	400	12	3	15	45 (3)	45	10 (5 CS-alone trials and 5 US-alone trials)	3 blocks of 30 extinction trials, each consisting of 20 CS-alone trials followed by 5 CS-alone and 5 US-alone trials presented pseudorandomly	Eyeblink amplitude exceeding 10% of baseline UR amplitude (measured during pseudoconditioning US-alone trials)	200–400
Bolbecker et al. (67)	350	15	10	10	100 (10)	90	8 US-alone trials	–	EMG amplitude over 5 SDs above pre-CS 125 ms baseline for each paired trial	100–350
Coesmans et al. (68)	500	Random intervals b/t 20 and 30	10	8	80 (10)	60	–	–	For paired and CS-alone trials, maximum eyelid closure occurring between 100 and 800 ms post-CS onset was first calculated. Blinks then classified as CRs if blink onset occurred within CR window (72)	150–525