Table 1.

LLNA/phenotypic analysis and total IgE dose response studies.

Dose group	LLNA (DPM)	% IgE + B220 + (% lymphocyte population)	%B220 + (% lymphocyte population)	Total IgE (ng/ml)
Acetone	208 ± 63	1.08 ± 0.49	13.91 ± 0.82	446 ± 106
2,3-Hexanedione
12.5%	385 ± 93	0.60 ± 0.31	16.22 ± 0.98	347 ± 78
25%	829 ± 257	1.39 ± 0.57	17.26 ± 0.94	409 ± 25
50%	3075 ± 720**	10.04 ± 2.69*	26.73 ± 1.03*	371 ± 133
Acetone	208 ± 63	1.08 ± 0.49	13.91 ± 0.82	445 ± 106
3,4-Hexanedione
12.5%	273 ± 77	0.95 ± 0.61	17.14 ± 1.46	353 ± 62
25%	1385 ± 390	4.18 ± 1.01	24.02 ± 2.38	325 ± 61
50%	3745 ± 334**	21.66 ± 3.11**	29.21 ± 1.80**	401 ± 45
Acetone	274 ± 49	1.23 ± 0.28	14.88 ± 1.59	354 ± 103
2,3-Heptanedione
12.5%	497 ± 97	1.71 ± 0.27	12.69 ± 1.22	491 ± 146
25%	2421 ± 252**	4.62 ± 0.92	17.05 ± 1.31	338 ± 54
50%	3970 ± 415**	22.26 ± 0.81**	26.26 ± 1.28*	587 ± 189
Acetone	389 ± 45	1.27 ± 0.11	10.29 ± 10.37	292 ± 110
2,3-Pentanedione
12.5%	560 ± 77	1.73 ± 0.47	12.20 ± 1.21	374 ± 118
25%	1584 ± 453	2.04 ± 1.18	15.00 ± 1.56	337 ± 120
50%	5230 ± 1152**	15.56 ± 1.14**	20.55 ± 2.21*	483 ± 143
Acetone	578 ± 116	1.50 ± 0.75	15.40 ± 1.05	332 ± 117
Diacetyl (Aldrich)
12.5%	1060 ± 110	2.59 ± 0.97	17.09 ± 1.29	387 ± 65
25%	2392 ± 536**	7.06 ± 1.54*	20.15 ± 1.91	450 ± 144
50%	4770 ± 430**	14.86 ± 4.32**	28.89 ± 1.56*	521 ± 133

Bars represent means ± SE of 5 mice per group.

Levels of statistical significance are denoted as *(p ≤ 0.05) and **(p ≤ 0.01) as compared to acetone vehicle.