Table 1.

Summary of Participants-Related Information

	LLD Diagnosis Prediction			LLD Treatment Response Prediction
Network	dDMN	aSN	Combined	dDMN	aSN	Combined
Number of ND	28 (b,c)	31 (b,c)	28 (b,c)	n/a	n/a	n/a
Number of LLD	27 (a,b,c)	25 (a,b,c)	22 (a,b,c)	24 (a,b,c,d)	22 (a,b,c,d)	19 (a,b,c,d)
Number of Responders	n/a	n/a	n/a	11	11	9
Number of Non-Responders	n/a	n/a	n/a	13	11	10
Age (years) [mean (standard deviation)]	70.20 (7.98)	70.00 (7.85)	69.78 (7.81)	68.83 (7.52)	68.36 (6.54)	67.37 (6.45)
Gender (% Female)	76.36%	78.57%	78.00 %	75.00%	81.82%	78.95%
Education (years) [mean (standard deviation)]	14.36 (2.45)	14.43 (2.51)	14.18 (2.40)	14.75 (2.75)	14.45 (2.69)	14.37 (2.75)
MMSE (score) [mean (standard deviation)]	28.40 (2.01)	28.32 (2.08)	28.36 (2.10)	27.58 (2.60)	27.41 (2.65)	27.26 (2.83)
HAM-D (score) before Treatment (e) [mean (standard deviation)]	20.33 (3.99)	20.24 (3.84)	20.50 (4.01)	20.42 (4.19)	20.32 (4.05)	20.63 (4.26)
HAM-D (score) after Treatment (e) [mean (standard deviation)]	10.08 (5.41) (f)	9.86 (5.75) (f)	10.11 (5.86) (f)	10.08 (5.41)	9.86 (5.75)	10.11 (5.86)

^(a)LLD participants (n=1) were omitted from the study due to excess head motion artifacts in fMRI image

^(b)ND (n=4) and LLD (n=2) participants were omitted from the study due to bad fMRI image registration to template

^(c)ND (dDMN: n=3; Combined: n=3) and LLD (dDMN: n=3; aSN: n=5; Combined: n=8) participants were omitted from the appropriate network-based analysis of this study due to bad ROIs registration to structural template

^(d)LLD (n=3) participants were omitted from the treatment response analysis of this study due to missing or partial HAM-D scores (this includes the only patient administered nimodipine)

^(e)Information regarding HAM-D scores is presented for LLD participants only.

^(f)HAM-D scores are missing for 3 participants and thus they were not included in the calculations.