Table 4.
Unadjusted and adjusted association of comorbity and demographic variables with Clostridium difficile infection (CDI) (OR, 95% CI)
| Univariate OR (95% CI) | Multivariate OR (95% CI) | |||
|---|---|---|---|---|
|
|
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| Comorbid Disease Category (referent is not treated for condition) | ||||
| Inflammatory Bowel Disease | 12.81 (11.75–13.97) | 11.42 (10.16–12.83) | ||
| Solid Organ Transplant | 7.76 (6.91–8.71) | 4.53 (3.92–5.24) | ||
| HIV | 6.16 (4.94–7.69) | 4.09 (3.16–5.30) | ||
| Hematopoietic stem cell transplantation | 19.38 (17.54–21.42) | 3.31 (2.87–3.82) | ||
| Neoplastic Disease | 6.84 (6.53–7.16) | 3.10 (2.89–3.31) | ||
| Fungal Infection | 13.28 (12.13–14.53) | 2.71 (2.39–3.07) | ||
| Cystic Fibrosis | 4.00 (3.47–4.61) | 2.65 (2.22–3.17) | ||
| Pancreatitis | 5.06 (4.44–5.77) | 2.86 (2.41–3.39) | ||
| Hematologic disorders | 5.16 (4.94–5.39) | 2.50 (2.34–2.66) | ||
| Gastrostomy | 6.81 (5.90–7.84) | 2.00 (1.67–2.39) | ||
| Liver Disease | 6.74 (6.11–7.42) | 2.04 (1.80–2.32) | ||
| Malnutrition | 8.50 (7.85–9.22) | 2.39 (2.14–2.67) | ||
| Renal disease | 6.81 (6.45–7.20) | 2.09 (1.99–2.19) | ||
| Systemic lupus erythematosus | 2.95 (2.36–3.70) | 2.06 (1.58–2.68) | ||
| Gastroesophageal reflux | 3.32 (3.04–3.63) | 1.97 (1.76–2.20) | ||
| Bacterial Infection | 2.57 (2.47–2.68) | 1.84 (1.74–1.94) | ||
| Cardiac disease | 2.06 (1.86–2.26) | 1.38 (1.23–1.56) | ||
| Appendicitis | 0.92 (0.82–1.02) | 1.46 (1.28–1.66) | ||
| Asthma | 0.53 (0.49–0.57) | 0.54 (0.49–0.59) | ||
|
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| Demographic Variables | Category | Referent | ||
|
| ||||
| Gender | Female | Male | 0.62 (0.60–0.65) | 0.83 (0.79–0.96) |
|
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| Race/Ethnicity | Black | 0.54 (0.50–0.58) | 0.63 (0.58–0.68) | |
| Hispanic | White | 0.78 (0.73–0.82) | 0.78 (0.74–0.83) | |
| Other | 0.86 (0.78–0.95) | 0.85 (0.77–0.94) | ||
|
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| Region | Midwest | 0.96 (0.90–1.02) | 0.94 (0.86–1.02) | |
| South | Northeast | 0.77 (0.73–0.81) | 0.80 (0.76–0.85) | |
| West | 1.14 (1.08–1.20) | 1.08 (1.02–1.15) | ||
|
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| Metropolitan Status | Urban | Rural | 1.90 (1.76–2.05) | 1.42 (1.29–1.59) |
|
| ||||
| Insurance | Public | 0.68 (0.65–0.71) | 0.80 (0.76–0.85) | |
| Uninsured | Private | 0.63 (0.58–0.68) | 0.80 (0.73–0.88) | |
|
| ||||
| KID Year | 2000 | 0.98 (0.91–1.06) | 1.07 (0.98–1.16) | |
| 2003 | 1997 | 1.24 (1.17–1.33) | 1.35 (1.25–1.46) | |
| 2006 | 1.75 (1.65–1.86) | 1.87 (1.74–2.01) | ||
Abbreviations: Odds Ratio (OR); Confidence Interval (CI)
Note: Results are obtained from fitting separate multivariable logistic regression models on the 4 years of KID data Univariate models regress CDI on individual covariates only. Multivariable models adjust for all covariates in the table as well as Age (data not shown).