Figure 1.

Relative positions of genetic loci and mutant alleles within the genetic and physical map regions around glp-4. (A) Displays the genetic map on the right arm of Chromosome I with morphologic loci in the region used to localize glp-4 indicated (top) and the physical map (bottom) of the region with genes that contain missense mutations from whole genome sequencing indicated. (B) Shows the intron–exon structure of Y87G2A.5, which encodes the cytoplasmic valyl aminoacyl transfer RNA synthetase VARS-2. (C) Shows an expansion of exon 3 with the relative position of glp-4 genetic lesions characterized in this paper indicated. Arrows in (B) and (C) are included to indicate the direction of transcription, with 3′ to the left. Diagrams are drawn to scale based on nucleotide position on Chromosome I. The tm3947 deletion spans nucleotide positions 13,555,971 to 13,556,472. The bn2, bn39, bn40 and oz283 point mutations occur at positions 13,556,729, 13,556,285, 13,556,288 and 13,556,310, respectively.