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. 2015 Oct 9;5(12):2729–2743. doi: 10.1534/g3.115.020974

Table 1. Neurospora crassa G protein−coupled receptor gene families and summary of growth/developmental and chemical sensitivity/nutrition phenotypes.

Fungal GPCR Class Description GPCR Class NCUa N. crassa Gene(s)b Saccharomyces cerevisiae Homologc Aspergillus nidulans Homologd Linear Growthe Asexual Developmentf Sexual Developmentg Chemical Sensitivityh/ Nutritioni
I Fungal Pheromone 05758 pre-2 STE2 gprA AH PP, P, Aj
II Fungal Pheromone 00138 pre-1 STE3 gprB P, Aj
III Carbon Sensory 06312 gpr-4 GPR1 None AH
IV Stm1-like 00300 gpr-5 YPQ1 AN5720 C
IV Stm1-like 09195 gpr-6 RTC2 AN5720 C
V cAMP Receptor-Like 00786 gpr-1 None AN8262 AH P C
V cAMP Receptor-like 04626 gpr-2 None AN8262 AH P
V cAMP Receptor-like 09427 gpr-3 None AN8262 AH P
VI GprK-like/RGS Domain 09883 gpr-7 None AN7795 (gprK) F
VII Rat growth hormone releasing factor receptor-like 03253 gpr-8 None AN6680 NAk
VIII mPR-Like/PAQR 03238 gpr-9 IZH3 AN4932 S
VIII mPR-like/PAQR 04987 gpr-10 IZH2 AN4932 F
IX Microbial Opsin 10055 nop-1 YRO2, MRH1, HSP30 AN3361 AH M
IX Microbial Opsin 01735 orp-1 YRO2, MRH1, HSP30 AN3361 AH
X Lung 7TM Superfamily 00182 gpr-11 PTM1 AN0063 YE
XI GPCR89/ABA GPCR 00005 gpr-12 YHR078w None
XII Family C-like 06629 gpr-13 None AN8601
XIII DUF300 superfamily/Ps GPR11 06987 gpr-14 YKR051W AN2232 NAk
XIVl Pth11-like 00700 gpr-15 None AN12202 R PP, P
Pth11-like 02903 gpr-16 None AN0178 AH F
Pth11-like 04106 gpr-17 None AN7774 AH
Pth11-like 04931 gpr-18 None AN10886 NAk
Pth11-like 05101 gpr-19 None AN1930 NAk
Pth11-like 05187 gpr-20 None AN8661 NAk
Pth11-like 05189 gpr-21 None AN8661
Pth11-like 05307 gpr-22 None AN0751 AH
Pth11-like 05829 gpr-23 None AN0751 R AH C,T
Pth11-like 05854 gpr-24 None AN8971 FL
Pth11-like 06531 gpr-25 None AN5639 C
Pth11-like 17171 gpr-26 None AN5664 NAk
Pth11-like 07538 gpr-27 None AN5664 F
Pth11-like 16721 gpr-28 None AN2249 NAk
Pth11-like 07649 gpr-29 None AN8943 R AH S,C
Pth11-like 07769 gpr-30 None AN4452 AH
Pth11-like 08429 gpr-31 None None I AH F
Pth11-like 08431 gpr-32 None AN5664 A
Pth11-like 08447 gpr-33 None AN5664
Pth11-like 08624 gpr-34 None AN0178
Pth11-like 08718 gpr-35 None AN8951
Pth11-Like 09022 gpr-36 None AN5664 A
Pth11-like 09201 gpr-37 None AN5664
Pth11-like 09796 gpr-38 None AN8328 R
Pth11-like 09823 gpr-39 None AN1930 AH A

GPCR, G protein−coupled receptor; NCU, N. crassa gene number.

a

Based on the Broad Institute’s Neurospora crassa database (http://www.broadinstitue.org/annotation/genome/neurospora/MultiHome.html).

b

N. crassa gene names are from the literature or designated during this study.

c

Yeast orthologs were obtained after a Blastp search of the NCBI database, using a cut-off score of e-05 or less.

d

A. nidulans orthologs were obtained from a Blastp search of the NCBI database, using a cut-off score of e-05 or less. Only the top hit is shown.

e

R, reduced growth rate; I, increased growth rate relative to wild type.

f

Defects in aerial hyphae (AH) or conidial development (C).

g

Defects in protoperithecial (PP), perithecial (P), and/or ascospore (A) development.

h

Chemical sensitivity phenotypes are indicated based on sensitivity or resistance to sorbitol (S), cytochalasin A (C), benomyl (B), tert-butyl hydroperoxide (T), menadione (M), FK506 (F), and fludioxonil (FL).

i

Represented by increased or decreased growth on Avicel (A) or Yeast Extract (Y) compared with wild type.

j

Mating type dependent.

k

Not available; see Table S1 for details.

l

Category XIV named in this study.