Table 1. Comparison of SMRT sequences and Illumina exome sequences for MYD88 exon 5 (chromosome 3).

DNA Source	Position in MYD88 Exon 5 Amplicon
	19t		+58g		+1245a		+1524t
	SMRT	Illumina	SMRT	Illumina	SMRT	Illumina	SMRT	Illumina
Tumor DLBCL773	8t + 65C	8t + 22C	73g	All g	3a + 70G	1G	73t	No reads
Tumor DLBCL778	17t + 73C	5t + 44C	90g	All g	90a	No reads	90t	No reads
Tumor DLBCL799	26t + 29C	16t + 21C	37g + 18T	5g + 4T	55a	No reads	55t	No reads
Tumor DLBCL816	88t + 19C	8t + 3C	107g	All g	53a + 54G	No reads	107t	No reads
Tumor DLBCL894	165t + 50C	27t + 14C	215g	All g	315a	No reads	315t	No reads
Tumor DLBCL832	75t	All t	75g	All g	75a	No reads	75t	No reads
Cell line Ly3	79C	2t + 10C	79g	All g	79G	No reads	63t + 16A	No reads
Cell line Ly10	16t + 28C	7t + 5C	44g	All g	16a + 28G	No reads	44t	No reads
Cell line SKI	310t	All t	310g	All g	151a + 159G	No reads	310t	No reads
Cell line Karpas422	11t	All t	11g	All g	11a	No reads	11t	2t
Cell line Ly1	121t	All t	121g	All g	121a	No reads	121t	No reads

Bases deviating from the reference are uppercase bold. The variant position within exon 5 is numbered relative to the start of the exon. Variants detected downstream of exon 5 are designated “+” and numbered relative to the end of the exon. No reads on the Illumina platform denotes no sequence mapped to a particular region.