Table 2.
Univariate and multivariate analyses of prognostic parameters for overall survival
| Variables | Univariate Analyses | Mutivariate Analyses | ||||
|---|---|---|---|---|---|---|
| P (Cox regression) | HR | 95 % CI | P (Cox regression) | HR | 95 % CI | |
| Age | 0.035 | 1.05 | 1.01-1.09 | 0.004 | 1.08 | 1.03-1.14 |
| Gender | 0.654 | 1.19 | 0.56-2.55 | - | - | - |
| ECOG PS (0 vs. 1–2) | 0.129 | 1.72 | 0.85-3.46 | - | - | - |
| Child-Pugh (A vs. B) | 0.011 | 2.52 | 1.24-5.13 | 0.142 | 2.72 | 0.72-10.31 |
| Tumor size (cm) | 0.016 | 1.52 | 1.08-2.15 | 0.008 | 1.66 | 1.14-2.40 |
| preAFP (ng/mL) | 0.436 | 1.00 | 1.00-1.00 | - | - | - |
| ALT | 0.898 | 1.01 | 0.99-1.01 | - | - | - |
| Albumin | 0.050 | 0.53 | 0.28-1.00 | 0.379 | 1.62 | 0.55-4.72 |
| Bilirubin | 0.027 | 1.58 | 1.05-2.36 | 0.258 | 1.43 | 0.77-2.70 |
| INR | 0.065 | 7.99 | 0.88-72.87 | 0.400 | 4.48 | 0.14-146.79 |
| Radiation dose | 0.018 | 0.94 | 0.89-0.99 | 0.079 | 0.95 | 0.90-1.01 |
| AFP normalization (yes vs. no) | 0.028 | 0.45 | 0.22-0.92 | 0.005 | 0.31 | 0.14-0.70 |
Abbreviations: HR hazard ratio, CI confidence interval, ECOG Eastern Cooperative Oncology Group performance status, HBs-Ag hepatitis B surface-antigen, preAFP pre-treatment alpha-fetoprotein, ALT alanine aminotransferase, INR international normalized ratio