Table 1.
Comparisons of demographic, clinical and behavioral characteristics of premanifest and early-HD gene-carrier participants; FET = Fisher’s Exact Test
| Premanifest-HD | Early-HD | Statistic | P-Value | |
| Age (mean, sd) | 42.5 (7.9) | 49.4 (10.1) | t(81.3) = 3.55 | <0.001 |
| Sex (female, %) | 20 (51%) | 29 (64%) | X (1) = 1.489 | 0.222 |
| Education (median) | 4 | 4 | FET = 3.947 | 1 |
| Site (no.) London | 16 | 18 | X (2) = 0.013 | 0.994 |
| Paris | 16 | 19 | ||
| Leiden | 7 | 8 | ||
| CAG Repeat (mean, range) | 42.85 (39–48) | 43.33 (39–49) | t(82) = 0.667 | 0.507 |
| CPO (mean, sd) | 0.229 (0.15) | 0.539 (0.23) | t(82) = 7.137 | <0.001 |
| HADS depression (mean, sd) | 2.97 (3.58) | 4.71 (4.39) | t(82) = 1.97 | 0.053 |
| PBA Irritability and Aggression (mean, sd) | 2.23 (3) | 4.38 (5.2) | t(72) = 2.356 | 0.021 |
| PBA Apathy (mean, sd) | 2.45 (4.08) | 5.53 (5.66) | t(76.1) = 2.84 | 0.006 |