Figure 4.

Mendelian randomisation analysis of the association of the smoking increasing allele (minor allele) of rs1051730/rs16969968 with systolic blood pressure (SBP) and diastolic blood pressure (DBP) and resting heart rate (RHR). Analyses were stratified by smoking status (current, former, and never smoking). The difference per one allele was estimated by linear regression adjusted for sex and age. Overall test for heterogeneity by smoking status: SBP: P=0.656; DBP: P=0.138; RHR: P=0.015;