Table 1.

Mendelian randomization meta-analysis: results of meta-analysed estimates of the association of the smoking increasing allele of rs16969968/rs1051730 with continuous measures of blood pressure, binary measures of hypertension (hypertension and severe hypertension), and the continuous measure of resting heart rate. Results were stratified by smoking status.

	Never smokers	Former smokers	Current smokers
Systolic blood pressure beta-coefficient* (95% CI); mmHg/allele	−0.07 (−0.28; 0.13) P = 0.479	−0.03 (−0.31; 0.25) P = 0.824	−0.20 (−0.46; 0.06) P = 0.136
Diastolic blood pressure beta-coefficient* (95% CI); mmHg/allele	0.01 (−0.12; 0.14) P = 0.879	0.08 (−0.09; 0.26) P = 0.331	−0.15 (−0.32; 0.02) P = 0.079
Hypertension Odds ratio* (95% CI) per allele	1.00 (0.97; 1.03) P = 0.923	1.00 (0.96; 1.03) P = 0.811	0.98 (0.95; 1.02) P = 0.277
Severe hypertension Odds ratio* (95% CI) per allele	1.02 (0.98; 1.05) P = 0.362	1.01 (0.97; 1.05) P = 0.543	0.96 (0.92; 1.00) P = 0.061
Resting heart rate beta-coefficient* (95% CI); beats/minute/allele	0.03 (−0.11; 0.17) P = 0.686	0.15 (−0.03; 0.33) P = 0.109	0.36 (0.18; 0.54) P < 0.001 †

^*associations have been adjusted for sex and age by linear (continuous outcomes) or logistic (binary outcomes) regression

^†Bonferroni-adjusted (15 tests) P-value was 0.001

CI confidence interval