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editorial
. 2014 Feb;13(1):8–12.

Table 1.

The Critical Roles of Glutathione

  1. Direct chemical neutralization of singlet oxygen, hydroxyl radicals, and superoxide radicals

  2. Cofactor for several antioxidant enzymes

  3. Regeneration of vitamins C and E

  4. Neutralization of free radicals produced by Phase I liver metabolism of chemical toxins

  5. One of approximately 7 liver Phase II reactions, which conjugate the activated intermediates produced by Phase I to make them water soluble for excretion by the kidneys

  6. Transportation of mercury out of cells and the brain

  7. Regulation of cellular proliferation and apoptosis

  8. Vital to mitochondrial function and maintenance of mitochondrial DNA (mtDNA)