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. Author manuscript; available in PMC: 2016 Mar 3.
Published in final edited form as: Biochemistry. 2015 Feb 19;54(8):1681–1693. doi: 10.1021/bi501171r

Figure 1. Alignment of gp41 amino acid sequence highlighting the MPER from the HXB2 and the JRFL strains.

Figure 1

Gp41 begins at the N-terminus with the fusion peptide (FP) followed by the N-terminal heptad repeat (NHR), a loop, the C-terminal heptad repeat (CHR), a membrane proximal external region (MPER), and a transmembrane domain (TM) followed by a C-terminal cytoplasmic region (C-tail). The alignment of gp41 amino acid sequence was done using CLC Main Workbench 7.5.1. The numbering is shown based on HXB2 strain and the matching residues shown as dots. The boxed area indicates the MPER region. We made 23 alanine substitutions in both strain HXB2 and strain JRFL.