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Xenopus laevis expressing bP23H rhodopsin in rods exhibited retinal degeneration when kept in cyclic light. (A) Wild-type tadpole kept in darkness (WT-D). (B) Wild-type tadpole kept in two light cycles (WT-L). (C) bP23H-expressing tadpole kept in darkness (bP23H-D). (D) bP23H-expressing tadpole kept in two light cycles totaling 24 hours of light (12L:12D:12L:12D) (bP23H-L). INL, inner nuclear layer; L, lens; ONL, outer nuclear layer. Scale bar: 100 μm.
