Table 2. Functional categories of genes with expression patterns differentially associated with pregnancy in presence or absence of RA.

Biological process / Molecular function	Genes
Regulation of immune system process	HLA-DRB3, IL15
Metabolic process	ACAD11, DECR2, LCAT, PKD2, PNPLA2, IL15, CAMKK1
Regulation of catalytic activity	PKD2, IFI27, CAMKK1
Hormone transport	HLA-DRB3, CACNA1C
Cellular response to osmotic stress	PKD2, RCSD1
Neurogenesis	MAP1S, CTHRC1, CACNA1C, USH2A, ARHGDIA
Tissue morphogenesis	PKD2, CTHRC1, CCM2
Voltage-gated calcium channel activity	PKD2, CACNA1C
Endothelial cell migration	EPHB4, HDAC5
Protein binding	TNNI2, CACNA1C, RPH3AL, USH2A, DAAM2, RCSD1, MAP1S, PKD2, FAM101B, MYO7B, SH2D4A, SYTL2
Cofactor binding	SQLE, ACAD11, HSD11B2, MTO1
Hydrolase activity	CES2, HDAC5, LCAT, PNPLA2

Genes up-regulated in healthy pregnancy are shown in normal font, genes downregulated in healthy pregnancy are shown in italics, genes up-regulated in RA pregnancy are not underlined and genes downregulated in RA pregnancy are underlined.